CJC-1295 No DAC

CJC-1295 without DAC, also known as Mod GRF 1-29, is a synthetic 29-amino acid analog of the first 29 amino acids of growth hormone-releasing hormone (GHRH). The peptide is modified at four positions to slow proteolytic degradation but contains no Drug Affinity Complex (DAC).

The lyophilisate is produced according to high quality standards and verified with HPLC to a purity of ≥ 99%. Intended for controlled research into GHRH signaling and pulsatile GH release.

Research relevance

• GHRH receptor — research into receptor binding and pituitary signaling.
• Pulsatile GH release — models that preserve natural pulsatile release patterns.
• Short half-life — suitable for studies where sharp pulses are desirable (~30 min half-life in vitro).
• Combination studies — often evaluated in combination with ghrelin receptor agonists such as ipamorelin or GHRP-6.

Frequently Asked Questions

What is CJC-1295 without DAC?

It is a modified GHRH(1-29) analog, also known as Mod GRF 1-29. The four amino acid modifications increase stability compared to native GHRH without altering receptor binding.

What is the difference compared to CJC-1295 with DAC?

The DAC (Drug Affinity Complex) variant binds to plasma albumin and has a half-life of days, resulting in a continuously elevated GH level. The variant without DAC works for only ~30 minutes, thereby retaining the pulsatile release characteristics.

What purity is guaranteed?

Every batch is analyzed by Janoshik Independent Peptide Analytics and achieves an HPLC purity of ≥ 99%.

How is CJC-1295 without DAC stored?

Store the lyophilisate refrigerated (2–8 °C), protected from light and moisture. Unopened vials are stable for a long time; only open just before reconstitution.

Disclaimer: Intended solely for research purposes. Not intended for human or animal consumption, medical, diagnostic, therapeutic, or cosmetic applications. The buyer is 18+ and confirms the research context.