MT2 (Melanotan II)

MT2 is a synthetic cyclic heptapeptide analog of α-MSH, developed in the 1980s at the University of Arizona as a broad-spectrum melanocortin receptor agonist. Within research, MT2 is studied for its non-selective binding to MC1R, MC3R, and MC4R and the resulting effects on pigmentation, appetite, and sexual signaling.

The MT2 lyophilisate is produced according to high quality standards and verified with HPLC to a purity of ≥ 99%.

Research relevance

• Multi-receptor melanocortin study — activates MC1R, MC3R, and MC4R simultaneously.
• MC1R pigmentation — classic model for eumelanin stimulation and skin pigment study.
• MC3R/MC4R signaling — models regarding central appetite and sexual activation.
• Comparison with PT-141 — PT-141 is more selective for MC3R/MC4R; MT2 also activates MC1R.

Frequently Asked Questions

What is MT2?

MT2 is a synthetic cyclic peptide developed by Hadley and Hruby at the University of Arizona in 1989. The cyclic structure (lactam bridge between Asp and Lys) significantly increases stability and receptor affinity.

How does MT2 differ from MT1?

MT2 is cyclic and non-selective (MC1R, MC3R, MC4R), whereas MT1 is linear and more selective for MC1R. Consequently, MT2 has a broader mechanistic research scope but less targeted signaling.

What purity is guaranteed?

Janoshik validates every batch for HPLC purity ≥ 99%.

How is MT2 stored?

Store the lyophilisate refrigerated (2–8 °C), protected from light and moisture. Only open vials immediately before reconstitution.

Disclaimer: Intended solely for research purposes. Not intended for human or animal consumption, medical, diagnostic, therapeutic, or cosmetic uses. Buyer is 18+ and confirms the research context.