Melanotan II is a synthetic cyclic peptide used in laboratory and preclinical research settings. It is based on a fragment of a naturally occurring melanocortin peptide and is used for studies focusing on peptide properties, molecular structure, and receptor interactions.
MT1, also known as Afamelanotide or [Nle_, D-Phe_]-α-MSH, is a synthetic linear 13-amino acid analog of the body’s own α-melanocyte-stimulating hormone. Two amino acid modifications increase stability and extend the half-life. Within research, MT1 is studied for its selective binding to the MC1R receptor and the subsequent eumelanin production.
MT1 lyophilisate is produced according to high quality standards and verified with HPLC to a purity of ≥ 99%.
Research relevance
MC1R receptor — selective agonist for the melanocortin-1 receptor.
Eumelanin production — classic model for melanocyte stimulation and pigmentation research.
Photoprotection models — preclinical studies on UV protection via increased eumelanin levels.
Erythropoietic protoporphyria research — models regarding UV tolerance in EPP.
Frequently Asked Questions
What is MT1?
MT1 is a modified linear variant of α-MSH with two amino acid modifications (Nle, D-Phe) that significantly increase its stability against enzymatic degradation.
How does MT1 differ from MT2?
MT1 is linear, MT2 is cyclic. MT1 has higher selectivity for MC1R; MT2 also activates MC3R and MC4R, resulting in additional effects on appetite and sexual signaling.
What purity is guaranteed?
Janoshik validates every batch for HPLC purity ≥ 99%, with additional analysis of heavy metals and endotoxins.
How is MT1 stored?
Store the lyophilisate refrigerated (2–8 °C), protected from light and moisture. Open vials only immediately before reconstitution.
Disclaimer: Intended for research purposes only. Not intended for human or animal consumption, medical, diagnostic, therapeutic, or cosmetic uses. Buyer is 18+ and confirms the research context.
