Description
Melanotan II is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH), originally developed to increase natural skin pigmentation and thereby provide protection against UV radiation. It is a cyclic heptapeptide with high affinity for melanocortin receptors.
Preclinical Benefits and Observations
Melanotan II increases melanin production through activation of MC1R, leading to a darker and more even tan with less UV damage. Additionally, it influences MC3R, MC4R, and MC5R, resulting in the regulation of appetite, energy metabolism, immune response, libido, and sexual function. It is particularly known for enhancing sexual arousal, suppressing appetite, and promoting weight loss.
Mechanism of action
Melanotan II activates multiple melanocortin receptors:
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MC1R: stimulates melanin production in the skin
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MC3R and MC4R: regulate appetite and inflammation
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MC5R: affects sweat and sebaceous glands, skin repair, and libido
Melanotan 2 binds to G-protein-coupled receptors, activates the cAMP pathway, and influences neuronal and hormonal signaling patterns that lead to skin pigmentation, increased motivation, improved sexual function, and metabolic effects.
Side Effects and Safety
Possible side effects include nausea, flushing, increased pigmentation of moles, and spontaneous erections. Long-term safety is still being investigated, partly due to uncertainty regarding the risks of melanoma formation.
Storage and Use
Melanotan II is supplied as a lyophilisate, stored refrigerated and dry, and used exclusively for research. Dosage and use must be strictly medically supervised.
